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O-linked Glycans

O-glycosylation is a common covalent modification of serine and threonine residues of mammalian glycoproteins. The most common type of O-glycosylation found on secreted mammalian glycoproteins and mucins (proteins conjugated to carbohydrate) is from the addition of N-acytylgalactosamine (GalNac) to serine or threonine residues. The Core 1 structure is generated by the addition of galactose b1-3 to this GalNAc. The Core 2 structure is generated by the further addition of N-acetyl-glucosamine b1-6 to the N-acetyl-galactosamine on the Core 1 structure. In total eight different core structures have been identified and all of these can be further elongated by the addition of a number of monosaccharides including sialic acids. These O-glycans are present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel) and human Factor VIII (FVIII).

Core 1 and Core 2 O-glycans are also present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel), humanFactor VIII(FVIII), Factor IX and insulin glargine.

The Ludger standards have a purity of > 90% as assessed by HILIC-HPLC and can be used as internal references or system suitability standards for peak assignment during HPLC or UPLC analysis.

Core 1, unlabeled, C1

Galactose-ß-(1-3)-GalNAc Glycan

20 micrograms
383.4 daltons

Part Number: SA-CORE1

Core 1 2-AB, C1

2-AB labelled Core 1 O-glycan, C1

View product documentation as PDF

100 picomoles

Part Number: CAB-C1-01

Core 1 sialylated 2-AB,C1S(3)1

2AB labelled sialylated core 1 O-glycan, C1S(3)1

View product documentation as PDF

50 picomoles

Part Number: CAB-C1S(3)1-02

Core 1 disialylated 2-AB, C1S(3,6)

2AB labelled di-sialylated core1 O-glycan, C1S(3,6)2

View product documentation as PDF

50 picomoles

Part Number: CAB-C1S(3,6)2-01

core 2 disialylated 2-AB,C2S(3,3)2

2AB labelled di-sialylated core 2 O glycan, C2S(3,3)2

View product documentation as PDF

100 picomoles

Part Number: CAB-C2S(3,3)2-02

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